
A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.
Cast

Chris Rock
Osmosis Jones (voice)

Laurence Fishburne
Thrax (voice)

David Hyde Pierce
Drix (voice)

Brandy Norwood
Leah (voice)

Elena Franklin
Shane Detorre

Bill Murray
Frank Detorre

William Shatner
Mayor Phlegmming (voice)

Ron Howard
Tom Colonic (voice)

Kid Rock
Kidney Rock (voice)

Molly Shannon
Mrs. Boyd

Chris Elliott
Bob

Jonathan Adams
Officer Tom (voice)

Carlos Alazraqui
Spanish Germ (voice)
Keith Anthony
Additional Character Voices (voice)

Eddie Barth
Conductor (voice)

Sally Brooks
Additional Character Voices (voice)

Rodger Bumpass
Joe Cramp / Announcer for Nerve News Network (voice)
Michael Carven
Additional Character Voices (voice)
Paul Christie
Dan Matter / Germ (voice)

Janis Dardaris
Additional Character Voices (voice)
Wendy Dillon
Additional Character Voices (voice)

Antonio Fargas
Chill the Flu Shot (voice)

Eddie Frierson
Frank Police Department Officer (voice)

Donald Fullilove
Doughnut (voice)

Jackie Gonneau
Additional Character Voices (voice)
Shannon Gregory
Additional Character Voices (voice)

Richard Steven Horvitz
Additional Character Voices (voice)

Rif Hutton
Charlie (voice)
Art Kimbro
Additional Character Voices (voice)
Joyce Kurtz
Additional Character Voices (voice)

Anne Lockhart
Female Red Blood Cell (voice)

Sherry Lynn
Trudy (voice)

Danny Mann
Musician Cell (voice)

Mickie McGowan
Brain Librarian (voice)
Kenny Olson
Kidney Rock Band (voice)
Jason Krause
Kidney Rock Band (voice)
Joe C.
Kidney Rock Band (voice)
Stefanie Eulinberg
Kidney Rock Band (voice)
Jimmie Bones
Kidney Rock Band (voice)
Uncle Kracker
Kidney Rock Band (voice)

Joel Silver
Police Chief (voice) (uncredited)
David Ossman
Scabies (voice) (uncredited)

John Melendez
Artie (voice)

Héctor Mercado
Additional Character Voices (voice)

Paul Pape
Male Red Blood Cell #2 (voice)
Marilyn Pasekoff
Additional Character Voices (voice)

Chris Phillips
Firefighter Doug (voice)
Lynne Redding
Additional Character Voices (voice)

Al Rodrigo
Frank Police Department Walkie Talkie (voice)

Herschel Sparber
Bruiser (voice)
Doug Stone
Police Officer Jamie (voice)
Steve Susskind
Mob Boss Germ (voice)

Keri Tombazian
Additional Character Voices (voice)

Paul Tuerpe
Additional Character Voices (voice)

Robert Wisdom
Big Germ (voice)

Danny Murphy
Zookeeper Superintendent
Jack McCullough
Zookeeper
Will Dunn
Oyster Boy

Jackie Flynn
School Janitor
Kelsey Jordan
Bus Girl #1

Abe Farrelly
Bus Girl #2
Jesse Peter
Laughing Boy
John-Eliot Jordan
Pea Soup Manager
Nancy Byers
Pea Soup Supervisor

Kevin J. Flynn
Docky's Clamshack Waiter

Sean Gildea
Dreamy Photographer
Kathryn Frick
Nurse #1

Nikki Tyler-Flynn
Nurse #2
Elizabeth Jordan
Nurse #3

Zen Gesner
ER Doctor #1
Marc Hyman
ER Doctor #2

Zak Penn
ER Doctor #3
Diane Conrad
Zoo Visitor or Staff
Judith Conrad
Zoo Visitor or Staff
Thomas Jordan
The Zoo Visitor or Staff
Sydney J. Bartholomew Jr.
Zoo Visitor or Staff
Erica Johnson
Zoo Visitor or Staff
Bo Cleary
Pea Soup Staff
Bruce McIntyre
Pea Soup Staff
Colleen O'Donnell
Docky's Clamshack
Docky
The Bikini Gang
Joe Murphy
The Bikini Gang
Brian Mone
Police Officer
Sean Fitzgerald
Police Officer
Grace Costa
ER Nurse
Emily O’Donnell
School Girl
Crew

Peter Farrelly
Director, Producer

Bobby Farrelly
Director, Producer
Marc Hyman
Screenplay
Stephen Schaffer
Editor
Lois Freeman-Fox
Editor
Sam Seig
Editor

Mark Irwin
Director of Photography
Hal Olofsson
First Assistant Director

Bob Camp
Storyboard
Steve Fonti
Storyboard
Daan Jippes
Storyboard

Mark Andrews
Storyboard
Barry Caldwell
Storyboard

Moroni Taylor
Storyboard Artist

Zak Penn
Producer

Bradley Thomas
Producer
Dennis Edwards
Producer

John Walker
Associate Producer
Aaron Parry
Associate Producer
Marc S. Fischer
Co-Producer
Sydney J. Bartholomew Jr.
Production Design
Jeannine Berger
Post Production Supervisor
Rick Montgomery
Casting
Pamela Withers
Costume Design
Adam Beck
Animation
Paul Dutton
Animation
Eddie Rosas
Animation
Craig R. Maras
Animation
Randy Sanchez
Animation
John Williamson
Animation
Sam Chou
Animation
Joe Giampapa
Animation

Shane Prigmore
Animation
Darlie Brewster
Supervising Animator
Ricardo Curtis
Supervising Animator
Brenda McNally
Hair Department Head
Joe Rossi
Makeup Department Head
Katherine C. Concepcion
Art Department Manager

Randy Thom
Sound Designer
William 'Billy Jack' Jakielaszek
Special Effects Coordinator
Steven Burch
Special Effects Supervisor
John Bermudes
Special Effects
John Harajovic
Special Effects
Ian Mah
Visual Effects Supervisor
Earl A. Hibbert
Visual Effects

Randy Edelman
Original Music Composer
Ken Ross
Music Supervisor
Scott Jacobson
Set Decoration
Leon Delaney
Stunt Coordinator

Alan J. Hagge
Systems Administrators & Support
Stephan Franck
Lead Animator
Audrey Stedman
Layout
Karen Hamrock
Layout
Bill Perkins
Layout
Jennifer Yuan
Layout
James P. Alles
Layout

Louis Gonzales
Layout
Hani D. El-Masri
Visual Development
Darek Gogol
Visual Development
Kevin Johnson
Visual Development
Chris Aguirre
Visual Development
Jeff Etter
Visual Development
Ricardo F. Delgado
Visual Development

Ruben Chavez
Visual Development
Fred Cline
Visual Development
Arlan Jay Vetter
Art Direction
Carol Koch
Sculptor
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